This book is the last from a cycle of books where I attempted to analyze when and why appeared the civilization. Back in 2006 with The Real World, I investigated a nonlinear-complex background on which we have built our alleged "world of order." In 2015 I continued with Solovki Ersatz, where, to my disappointment, I was not ready to provide a fair answer. Finally, in 2019, I fulfilled my desire to unveil such a hard to crack a nut, and the answer was shaped in the book Emergency of Modern Brain and the Imaginary Build-Up of Civilization. Later in 2019, I completed the topic with another book that is the current one. The entire cycle of books analysis the answers humans give to the issue of "uncertainty." "Uncertainty" contains the complexity of very many ways of doing, but when the right way is not appropriately guessed, the unsolved issues might turn into an existential threat. "Uncertainty" is entropy, and all biological systems exist because of a generated "negentropy" (that is a drastic reduction in the inner entropy) that allows every living systems to adjust to a minimum of environmental information that can be managed its way by each species. Each species has its own "world of order" the same way we have ours. Knowing more increases the size of the unknown. Because of this paradox, and because, in fact, augmenting everything, our civilization generated exponentially high levels of "uncertainty." The enlarged "uncertainty" takes now the form of stress. It is the stress of "uncertainty". However, stress seems to be the cause of all diseases affecting humanity.