* Explores the role of CK2 as a target in cancer treatment * Written by an international group of experts in the field * Covers the molecular, structural and functional aspects of CK2 * Includes appendix with information on the implication of CK2 in non-oncologic diseases .
The importance of CK2 in cancer and other diseases has generated a significant amount of literature on the protein, and an international community of CK2 researchers. The International Union of Biochemistry and Molecular Biology (IUMBMB) sponsors periodic international conferences on CK2, making the protein a natural topic for a Wiley-IUBMB publication.
Protein Kinase CK2 will deal with structural aspects underlying the constitutive activity of CK2, its specific susceptibility to pharmacological inhibition and its extraordinary pleiotropy. In the second part the fundamental role of CK2 in a wide number of biological functions will be illustrated, while the third part will be devoted to the unusual mode of implication of CK2 in neoplastic transformation, with an appendix reviewing its potential relevance to other pathologies.
